Autologous bone marrow transplantation in chronic myeloid leukaemia.

Selected Summarie

8 Reiffers J, Goldman J, Meloni G, Cahn JY, Gratwohl A. Autologous stem cell transplantation in chronic myelogenous leukaemia: A retrospective analysis of the European Group of Bone Marrow Transplantation. Bone Marrow Transplanl1994; 14:407-10. 9 Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC. Long term marrow culture reveals chromosomally normal haematopoietic progenitor cells in patie...

Prospects for cure in leukaemia.

Patients with acute leukaemia have normal or near normal numbers of haemopoietic stem cells in their marrow at diagnosis. Remission is achieved when the administration of cytotoxic drugs eradicates the bulk of the leukaemic population while sparing normal haemopoiesis. The mechanism by which chemotherapy seems to act in this selective manner is essentially unknown. Nevertheless, remission rates...

Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow

Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...

The prothrombin gene 3'-untranslated region mutation is frequently associated with factor V Leiden in thrombophilic patients and shows ethnic-specific variation in allele frequency.

1. Spencer A, O’Brien SG, Goldman JM: Options for therapy in chronic myeloid leukaemia. Br J Haematol 91:2, 1995 2. Bhatia R, Verfaillie CM, Miller JS, McGlave PB:Autologous transplantation for chronic myelogenous leukemia. Blood 89:2623, 1997 3. Cullis JO, Schwarer AP, Hughes TP, Hows JM, Franklin I, Morgenstern G, Goldman JM: Second transplants for patients with chronic myeloid leukaemia in r...

Autologous bone marrow transplantation for patients with acute myeloid leukaemia: prospective follow-up study.

OBJECTIVE To study the use of autologous bone marrow transplantation to treat acute myeloid leukaemia when complete remission had been achieved and when no human leukocyte antigen matched related donor was available. DESIGN Prospective follow-up study. SETTING Government hospital, Hong Kong. PATIENTS Eight patients (median age, 34 years [range, 16-45 years]) with acute myeloid leukaemia i...

Splenic irradiation before bone marrow transplantation for chronic myeloid leukaemia.